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KMID : 0923620110110060406
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Immune Network
2011 Volume.11 No. 6 p.406 ~ p.411
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Comparison of Invariant NKT Cells with Conventional T Cells by Using Gene Set Enrichment Analysis (GSEA)
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Oh Sae-Jin
Ahn Ji-Ye
Chung Doo-Hyun
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Abstract
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Background: Invariant Natural killer T (iNKT) cells, a distinct subset of CD1d-restricted T cells with invariant V?? TCR, functionally bridge innate and adaptive immunity. While iNKT cells share features with conventional T cells in some functional aspects, they simultaneously produce large amount of Th1 and Th2 cytokines upon T-cell receptor (TCR) ligation. However, gene expression pattern in two types of cells has not been well characterized.
Methods: we performed comparative microarray analyses of gene expression in murine iNKT cells and conventional CD4＋CD25???TCR? T cells by using Gene Set Enrichment Analysis (GSEA) method.
Results: Here, we describe profound differences in gene expression pattern between iNKT cells and conventional CD4＋CD25???TCR? T cells.
Conclusion: Our results provide new insights into the functional competence of iNKT cells and a better understanding of their various roles during immune responses.
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KEYWORD
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NKT cells, conventional T cells, Microarray, GSEA
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